I am group leader of the work group “Osteoarthritis & Cartilage Regeneration” and head of Experimental Rheumatology (a.i.) My research interests include, but are not limited to, the pathobiology of osteoarthritis with a special interest in the role of growth factors and cytokines (e.g. TGF beta, BMPs, Wnts) in pathological processes, such as tissue destruction, inflammation and fibrosis, and its changing roles during ageing. Research is focused on the elucidation of the mechanism of tissue destruction in osteoarthritis and application of this knowledge in the prevention of tissue damage and the stimulation of tissue regeneration. Research covers the continuum from cartilage destruction, synovial inflammation, fibrosis and osteophyte formation to cartilage regeneration. To elucidate the pathological mechanisms, we use in vitro cell culture systems, viral over expression systems both in vitro and in vivo, tissue specific, inducible animal models and human tissues.